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Anti-tick-borne encephalitis (TBE) virus neutralizing antibodies dynamics in natural infections versus vaccination
Maria Elena Remoli1, Antonella Marchi2, Claudia Fortuna2
1Department of Infectious, Parasitic and Immune-Mediated Diseases, Unit of Viral Diseases and Attenuated Vaccines, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy mariaelena.remoli@iss.it.
Abstract:
Tick-borne encephalitis (TBE) virus infection elicits a life-long lasting protection. However, little is known about the neutralizing antibodies titres following natural infection. In this study, subjects with past TBE disease (n = 62) were analysed for the presence and titre of anti-TBE neutralizing antibodies, and compared with a vaccinated cohort (n = 101). Neutralizing antibody titres were higher in individuals with past TBE and did not show an age-dependent decrease when compared with vaccinees.
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