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Mania induced by opipramol.

Kazhungil Firoz1, Asfia Khaleel1, V Rajmohan1

  • 1Department of Psychiatry, MES Medical College, Perinthalmanna, Kerala, India.

Indian Journal of Psychological Medicine
|February 28, 2015
PubMed
Summary
This summary is machine-generated.

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Opipramol, an antidepressant, can trigger mania in bipolar disorder patients, contrary to expectations. This case study highlights the risk of manic switch even with atypical antidepressants acting on sigma receptors.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Antidepressants can induce manic switch in bipolar disorder patients.
  • Opipramol, an atypical anxiolytic and antidepressant, acts on sigma receptors.
  • It lacks norepinephrine/serotonin reuptake inhibition, suggesting low risk for manic switch.

Observation:

  • A patient with bipolar affective disorder experienced mania.
  • The patient was treated for a moderate depressive episode with lithium and opipramol.
  • This occurred despite opipramol not being presumed to cause manic switch.

Findings:

  • Opipramol induced mania in a bipolar disorder patient.
  • This challenges the assumption that sigma receptor-acting drugs are safe for bipolar depression.
Keywords:
Antidepressantsmaniaopipramolswitch

Related Experiment Videos

  • A neurochemical hypothesis for opipramol-induced mania is discussed.

    • Implications:

    • Clinicians should exercise caution when prescribing opipramol to bipolar patients.
    • Further research is needed to understand the neurochemical mechanisms of opipramol-induced mania.
    • This case underscores the importance of individualized risk assessment for antidepressant use in bipolar disorder.