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Dynorphin A(1-13) modulates apomorphine-induced behaviors using multidimensional behavioral analyses in the mouse
M Ukai1, T Toyoshi, T Kameyama
1Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
Brain Research
|October 16, 1989
Summary
Dynorphin A(1-13) inhibits apomorphine-induced rearing behaviors in mice, suggesting a role for kappa opioid receptors. This interaction may offer insights into modulating dopamine-related motor functions.
Area of Science:
- Neuropharmacology
- Behavioral Neuroscience
Background:
- Apomorphine is a dopamine receptor agonist known to induce behavioral changes.
- Dynorphin A(1-13) is an endogenous opioid peptide with complex receptor interactions.
Purpose of the Study:
- To investigate the effects of dynorphin A(1-13) on apomorphine-induced behaviors in mice.
- To explore the potential involvement of opioid receptors in these interactions.
Main Methods:
- Intracerebroventricular injection of dynorphin A(1-13) in mice.
- Administration of apomorphine at varying doses.
- Multidimensional behavioral analysis using a capacitance system.
- Assessment of the effects of an opioid antagonist (Mr2266).
Main Results:
- Apomorphine induced dose-dependent increases in rearing, locomotion, and circling.
- Dynorphin A(1-13) inhibited apomorphine-induced rearing.
- Dynorphin A(1-13) potentiated apomorphine-induced locomotion and circling at higher doses.
- The inhibitory effect of dynorphin A(1-13) on rearing was reversed by the opioid antagonist Mr2266.
Conclusions:
- Dynorphin A(1-13) exerts differential effects on apomorphine-induced behaviors.
- The antagonistic effect on rearing is likely mediated by kappa opioid receptors.
- These findings contribute to understanding opioid modulation of dopaminergic pathways.