Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Wilcoxon Signed-Ranks Test for Matched Pairs01:09

Wilcoxon Signed-Ranks Test for Matched Pairs

631
The Wilcoxon signed-rank test for matched pairs evaluates the null hypothesis by combining the ranks of differences with their signs. It essentially tests whether the median of the differences in a population of matched pairs is zero. Since the test incorporates more information than the sign test, it generally yields more trustable conclusions. This test also does not require the data to follow a normal distribution, but two conditions must be met for it to be applicable: (1) the data must...
631
Sign Test for Matched Pairs01:17

Sign Test for Matched Pairs

480
The sign test for matched pairs offers a robust method for comparing two paired samples, often for the effects of an intervention in one of them. This method is very useful in situations where the underlying distribution of the data is unknown. The test compares two related samples—often pre- and post-treatment measurements on the same subjects—to determine if there are significant differences in their median values.
To conduct the sign test, we first calculate the differences in...
480
Relationship Formation02:12

Relationship Formation

46.4K
What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
46.4K
Multiple Comparison Tests01:13

Multiple Comparison Tests

4.7K
Multiple comparison test, abbreviated as MCT, is a post hoc analysis generally performed after comparing multiple samples with one or more tests. An MCT will help identify a significantly different sample among multiple samples or a factor among multiple factors.
It would be easy to compare two samples using a significance alpha level of 0.05. In other words, there is only one sample pair to be compared. However, it would be difficult to identify a significantly different sample if the number...
4.7K
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

414
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
414
Mismatch Repair01:20

Mismatch Repair

7.2K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
7.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human RIG-I Antiviral Deficiency Caused by a Dominant-Negative Variant Locked in a Signaling-Inactive State.

medRxiv : the preprint server for health sciences·2026
Same author

Pol γ possesses separate metal binding sites for polymerase and strand displacement functions.

bioRxiv : the preprint server for biology·2026
Same author

Protocol to investigate human mitochondrial transcription initiation by integrating biochemical and cryo-EM approaches.

STAR protocols·2026
Same author

Human mitochondrial helicase Twinkle has RNA binding, annealing, and strand-exchange activities.

Nucleic acids research·2026
Same author

Torsion is a dynamic regulator of DNA replication stalling and reactivation.

Nature communications·2025
Same author

Human mitochondrial RNA polymerase structures reveal transcription start site and slippage mechanism.

Molecular cell·2025
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Same journal

Systematic discovery of pathogen effector functions across human pathogens and pathways.

Cell·2026
See all related articles

Related Experiment Video

Updated: Apr 16, 2026

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model
07:15

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model

Published on: August 16, 2020

7.7K

Finding the right match fast.

Divya Nandakumar1, Smita S Patel1

  • 1Department of Biochemistry and Molecular Biology, Rutgers-Robert Wood Johnson Medical School, 675 Hoes Lane West, Piscataway, NJ 08854, USA.

Cell
|February 28, 2015
PubMed
Summary
This summary is machine-generated.

DNA recombinases efficiently find target DNA sequences by searching in small, 8-nucleotide microhomology units. This strategy significantly speeds up the homology search process within the genome.

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

8.1K
Spotting Cheetahs: Identifying Individuals by Their Footprints
09:47

Spotting Cheetahs: Identifying Individuals by Their Footprints

Published on: May 1, 2016

15.5K

Related Experiment Videos

Last Updated: Apr 16, 2026

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model
07:15

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model

Published on: August 16, 2020

7.7K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

8.1K
Spotting Cheetahs: Identifying Individuals by Their Footprints
09:47

Spotting Cheetahs: Identifying Individuals by Their Footprints

Published on: May 1, 2016

15.5K

Area of Science:

  • Genetics
  • Molecular Biology
  • Biochemistry

Background:

  • DNA recombinases are enzymes crucial for genetic processes.
  • Locating specific DNA sequences in a large genome is a complex challenge.
  • Recombinases must perform homology searches rapidly to function effectively.

Purpose of the Study:

  • To elucidate the mechanism by which DNA recombinases efficiently search for target sequences.
  • To understand how recombinases accelerate homology searches within the genome.

Main Methods:

  • The study investigated the search strategy of DNA recombinases.
  • Analysis focused on the role of microhomology units in the search process.

Main Results:

  • DNA recombinases search for target sequences by examining 8-nucleotide microhomology units.
  • This approach effectively reduces the search space for homology detection.
  • The use of microhomology units significantly accelerates the overall homology search.

Conclusions:

  • DNA recombinases employ a microhomology-based search strategy to overcome the challenge of rapid sequence identification.
  • This mechanism is key to their efficiency in locating specific DNA sequences within the vastness of a genome.