[Study of IgE and T lymphocyte subsets in patients with serious bronchial asthma]

In the present study, 30 patients with serious asthma were selected for the investigation of IgE and T lymphocyte subsets in PBL. By the indirect McAb immuno-SPA assay, it was observed that the percentages of OKT3 and OKT8 but the percentage of OKT4 subset and T4/T8 ratio were significantly higher than those of normal persons (P less than 0.01). The total IgE in serum of patients (performed by ELISA) was also much higher than that of normal persons (P less than 0.05). In addition, there was a closed relationship between the level of IgE and the percentage of OKT of the patients (r = 0.37369, P less than 0.05). The results indicated that one of possible reasons of higher IgE in serum of asthma patients was the abnormality of T lymphocyte subsets in vivo.