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Updated: Apr 16, 2026

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Published on: November 1, 2019

Nucleic acid-based aptamers: applications, development and clinical trials.

Jagat R Kanwar¹, Kislay Roy, Nihal G Maremanda

¹Immunology & Cell Biology, Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research (NLIMBR), Deakin University, Geelong, Geelong Technology Precinct (GTP), Deakin University, Pigdons Road, Waurn Ponds, Geelong, Victoria 3217, Australia. jagat.kanwar@deakin.edu.au.

Current Medicinal Chemistry

|February 28, 2015

Summary

Aptamers, or chemical antibodies, offer superior specificity and stability over traditional antibodies. Their successful clinical trials show great promise for novel diagnostics and therapeutics.

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Area of Science:

Biotechnology
Molecular Biology
Drug Discovery

Background:

Aptamers are short oligonucleotides with high specificity and affinity, serving as alternatives to antibodies.
They offer advantages like stability, ease of modification, and manufacturing.
Aptamer chimeras combine aptamer functionalities with other molecules for diverse applications.

Purpose of the Study:

To review aptamer technology, focusing on production, selection, modifications, and clinical applications.
To highlight the role of aptamers in advanced detection systems and diagnostics.
To emphasize the therapeutic potential and clinical trial successes of aptamers.

Main Methods:

Iterative selection processes over 10-15 cycles from random nucleotide pools.
Chemical modifications, including locked nucleic acids (LNAs), to enhance stability and function.
Analysis of aptamer performance in clinical trials for various diseases.

Main Results:

Aptamers demonstrate high binding affinity and target specificity.
Aptamer-based detection systems show potential to replace traditional methods.
Numerous aptamers have entered clinical trials with favorable outcomes, indicating therapeutic relevance.

Conclusions:

Aptamers represent a significant advancement in biotechnology with broad therapeutic and diagnostic potential.
Their specificity, stability, and manufacturing advantages position them as key players in future medicine.
Clinical trial successes underscore the transformative impact of aptamers on disease treatment and management.