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Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
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The author replies:

Jai Radhakrishnan1

  • 1Division of Nephrology, Department of Medicine, Columbia University, New York, New York, USA.

Kidney International
|February 28, 2015
PubMed
Summary

No abstract available in PubMed .

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