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Age dependent changes in metallothionein and accumulation of cadmium in horses
E H Jeffery1, R Noseworthy, M G Cherian
1University of Illinois, Institute of Environmental Studies, Urbana 61801.
Abstract:
1. Analysis of livers and kidneys from 28 horses for cadmium, zinc and metallothionein showed low cadmium content in liver. There was a gradual increase in cadmium content in kidney with age. 2. Metallothionein values varied with zinc content in the liver and with cadmium content in the kidney; copper values did not vary in either tissue. 3. Metallothionein was localized mainly in the cytoplasms in liver and kidney of horses by immunohistochemistry.