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An overview of measuring impulsive behavior in mice
Claire L Dent1, Anthony R Isles
1Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom; School of Psychology, Cardiff University, Cardiff, United Kingdom.
Current Protocols in Mouse Biology
|February 28, 2015
Summary
Understanding impulsivity in psychiatric disorders requires examining response control. Mouse models help researchers dissect genetic influences on distinct impulsive behaviors, advancing therapy development.
Area of Science:
- Neuroscience
- Psychiatry
- Behavioral Science
Background:
- Impulsive behavior is central to psychiatric disorders like ADHD, schizophrenia, mania, and addiction.
- Maladaptive response control is a key feature of these conditions.
- Animal models, particularly rodents, are crucial for studying the neurological basis of impulsivity.
Purpose of the Study:
- To review behavioral tasks for assessing impulsivity in animal models.
- To highlight the importance of the non-unitary nature of response control.
- To guide the use of mouse models in understanding genetic contributions to impulsivity.
Main Methods:
- Review of established and novel behavioral tasks for response control assessment.
- Analysis of how these tasks can differentiate components of impulsivity.
- Focus on the application of these methods in mouse models.
Main Results:
- Behavioral tasks can distinguish between different facets of impulsivity.
- Mouse models offer a powerful tool to investigate genetic influences on these facets.
- Understanding dissociable components of impulsivity is key for accurate modeling.
Conclusions:
- Response control is complex and comprises distinct components.
- Mouse models are valuable for dissecting the genetic basis of psychiatric disorders characterized by impulsivity.
- This approach can inform the development of targeted therapies for impulse control disorders.
