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A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

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A Microfluidic Diffusion Cell for Fast and Easy Percutaneous Absorption Assays.

Christophe Provin¹, Alexandre Nicolas, Sébastien Grégoire

¹LIMMS/CNRS-IIS (UMI 2820), Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, 153-8505, Tokyo, Japan, cprovin@iis.u-tokyo.ac.jp.

Pharmaceutical Research

|March 1, 2015

Summary

This study introduces a novel microfluidic device for assessing topical compound absorption. The device offers a faster, more reproducible alternative to traditional methods for pharmaceutical and cosmetic development.

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Area of Science:

Biomedical Engineering
Materials Science
Pharmacokinetics

Background:

Percutaneous absorption assays are crucial for evaluating topical drug and cosmetic bioavailability.
Current methods using excised human skin have limitations including poor reproducibility and tedious setup.

Purpose of the Study:

To develop an alternative method for percutaneous absorption assays.
To overcome the limitations of traditional diffusion cell methods.

Main Methods:

Integration of an artificial stratum corneum model into a microfluidic device.
Incorporation of online optical sensors for real-time monitoring.
Development of a user-friendly, large-scale producible assay.

Main Results:

The device accurately measured diffusion profiles, permeability coefficients, and time lag for seven molecules, aligning with literature data.
The artificial stratum corneum coating demonstrated robustness and reproducibility.
The microfluidic system provided fast, real-time, accurate, and reproducible results.

Conclusions:

The proposed microfluidic device offers a significant advancement for assessing topical compounds.
This technology can accelerate the development of new pharmaceuticals and cosmetics by enabling more efficient candidate molecule evaluation.