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Updated: Apr 16, 2026

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Ischemic stroke with essential thrombocythemia: a case series.

Yuji Kato1, Takeshi Hayashi1, Yoshihide Sehara1

  • 1Department of Neurology and Cerebrovascular Medicine, Saitama International Medical Center, Saitama Medical University, Hidaka, Japan.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|March 1, 2015
PubMed
Summary

Essential thrombocythemia (ET) can cause stroke, even without high platelet counts. Early ET diagnosis and risk factor management are crucial to prevent recurrent strokes and thrombotic events.

Keywords:
Ischemic strokeJAK2 V617F mutationantiplatelet therapycytoreductive therapyessential thrombocythemia

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Area of Science:

  • Neurology
  • Hematology
  • Vascular Medicine

Background:

  • Essential thrombocythemia (ET) is an underdiagnosed cause of stroke, often missed if platelet counts are normal.
  • Prompt ET detection is vital due to high recurrence rates of thrombosis without effective treatment.

Purpose of the Study:

  • To investigate the clinical characteristics and stroke patterns in patients with Essential thrombocythemia.
  • To highlight the association between ET and cerebrovascular events, particularly watershed infarcts.

Main Methods:

  • Retrospective analysis of 10 stroke cases associated with ET.
  • Review of patient demographics, stroke details, laboratory findings (platelets, JAK2 V617F mutation), and treatments.

Main Results:

  • Most ET stroke patients had atherosclerotic risk factors; 80% had stroke as their first ET manifestation.
  • Watershed infarcts occurred in 30% of events, even without large artery stenosis.
  • Mean platelet count was 966 × 10^9/L; JAK2 V617F mutation present in 71% of tested patients.

Conclusions:

  • Essential thrombocythemia is a significant risk factor for stroke, predisposing to watershed infarcts.
  • Early ET diagnosis and aggressive management of vascular risk factors are essential for preventing recurrent cerebrovascular events.