Related Experiment Video
Updated: Apr 16, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Formulation and optimization of efavirenz nanosuspensions using the precipitation-ultrasonication technique for
Sakshi Taneja1, Satish Shilpi2, Kapil Khatri2
1a Department of Quality Assurance , ISF College of Pharmacy , Moga , Punjab , India.
Abstract:
Efavirenz is a non-nucleoside reverse transcriptase inhibitor, and is classified as BCS Class II API. Its erratic oral absorption and poor bioavailability make it a potential candidate for being formulated as a nanosuspension. The objective of this study was to formulate efavirenz nanosuspensions employing the antisolvent precipitation-ultrasonication method, and to enhance its solubility by reducing particle size to the nanometer range. The effects of different process parameters were studied and optimized with respect to particle size and poly dispersity index (PDI). The optimized formulation was also subjected to lyophilization, to further increase the solubility and stability, and the technology is potentially suited to a range of poorly water-soluble compounds.
More Related Videos
Related Concept Videos
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Bioavailability Enhancement: Drug Solubility Enhancement
Factors Influencing Drug Absorption: Pharmaceutical Parameters
In Vitro Drug Dissolution: Alternative Methods
Colloidal precipitates
Bioavailability Enhancement: Drug Permeability Enhancement

