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Changes in the Gastric Mucosa With Aging
Amnon Sonnenberg1, Robert M Genta2
1Miraca Life Sciences, Research Institute, Irving, Texas; Department of Medicine, Oregon Health and Sciences University, Portland, Oregon.
Summary
Gastric abnormalities increase with age, affecting 50% of individuals. Helicobacter pylori infection is a primary cause of these changes, though other causes remain unknown.
Area of Science:
- Gastroenterology
- Pathology
- Epidemiology
Background:
- Gastric mucosal health is crucial for digestive function.
- Age is a known factor influencing various physiological processes.
- Helicobacter pylori infection is a prevalent global health concern.
Purpose of the Study:
- To define age-related alterations in gastric mucosa.
- To assess the role of Helicobacter pylori in these changes.
Main Methods:
- Analysis of a large national pathology database (895,323 subjects).
- Inclusion of esophagogastroduodenoscopy and gastric biopsy data from 2008-2013.
- Stratification of histopathology prevalence by age, sex, and geographic location.
Main Results:
- Gastric abnormalities were found in 50% of subjects over a lifetime.
- Helicobacter pylori infection was linked to increased gastric abnormalities (22% prevalence).
- Reactive gastropathy, increasing with age, was the second most common finding (18% prevalence).
Conclusions:
- Gastric abnormalities are more prevalent with increasing age.
- Helicobacter pylori is a major contributor to gastric pathology.
- The etiology of numerous gastric abnormalities remains unidentified.
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