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Increased Platelet to Lymphocyte Ratio is Related to Slow Coronary Flow

Mehmet Kadri Akboga1, Ugur Canpolat2, Kevser Gulcihan Balci2

  • 1Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey mkakboga@yahoo.com.

Angiology
|March 1, 2015
PubMed

Insights

The platelet to lymphocyte ratio (PLR) is linked to slow coronary flow (SCF), a condition affecting heart arteries. Higher PLR levels independently predict the presence of SCF and correlate with inflammation markers.

Area of Science:

  • Cardiology
  • Inflammation Research
  • Biomarker Discovery

Background:

  • Inflammation and platelets are implicated in slow coronary flow (SCF).
  • Platelet to lymphocyte ratio (PLR) is an emerging inflammatory marker associated with cardiovascular events.

Purpose of the Study:

  • To investigate the association between PLR and SCF.
  • To determine if PLR is an independent predictor of SCF.

Main Methods:

  • Retrospective study including 221 patients with SCF and 293 controls.
  • SCF diagnosed using thrombolysis in myocardial infarction frame counts (TFC).
  • Analyzed PLR and C-reactive protein (CRP) levels.

Main Results:

  • PLR and CRP levels were significantly higher in the SCF group.
  • PLR showed a significant positive correlation with TFC in all coronary arteries and with CRP.
  • PLR was independently associated with the presence of SCF (OR: 1.014, P < .001).

Conclusions:

  • Elevated PLR is significantly and independently associated with the presence of SCF.
  • PLR correlates positively with CRP, indicating a link to systemic inflammation.

Keywords:
C-reactive proteincoronary slow flowinflammationplatelet to lymphocyte ratio

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