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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Related Experiment Video

Updated: Apr 16, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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TRP channels.

Silvia Benemei1, Riccardo Patacchini2, Marcello Trevisani3

  • 1Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy.

Current Opinion in Pharmacology
|March 1, 2015
PubMed
Summary
This summary is machine-generated.

Transient receptor potential (TRP) channels in sensory neurons play a key role in the cough reflex. Targeting these TRP channels could lead to new cough medicines.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Respiratory Medicine

Background:

  • Transient receptor potential (TRP) channels are expressed in primary sensory neurons involved in cough.
  • Specific TRP channels, including TRPV1, TRPA1, TRPV4, and TRPM8, are implicated in the cough reflex.

Purpose of the Study:

  • To explore the role of TRP channels in the cough mechanism.
  • To investigate how TRP channel agonists and proinflammatory conditions affect cough.
  • To examine the influence of drugs on cough via TRP channels.

Main Methods:

  • Review of accumulating evidence on TRP channel function in cough.
  • Analysis of selective stimuli for TRP channels in provoking or inhibiting cough.
  • Examination of drug off-target effects on airway irritation and cough mediated by TRP channels.

Main Results:

  • Selective stimuli for TRP channels can provoke cough.
  • Cough threshold to TRP agonists is elevated in proinflammatory states.
  • Drugs like tiotropium and desflurane may exert effects on cough through TRPV1 and TRPA1 channels.

Conclusions:

  • TRP channels are crucial in initiating and potentiating cough.
  • These channels are activated by external irritants and internal inflammatory mediators.
  • Further research into TRP channels may yield novel therapeutic strategies for cough treatment.