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TRP channels

Silvia Benemei1, Riccardo Patacchini2, Marcello Trevisani3

  • 1Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy.

Current Opinion in Pharmacology
|March 1, 2015
PubMed

Insights

Transient receptor potential (TRP) channels in sensory neurons play a key role in the cough reflex. Targeting these TRP channels could lead to new cough medicines.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Respiratory Medicine

Background:

  • Transient receptor potential (TRP) channels are expressed in primary sensory neurons involved in cough.
  • Specific TRP channels, including TRPV1, TRPA1, TRPV4, and TRPM8, are implicated in the cough reflex.

Purpose of the Study:

  • To explore the role of TRP channels in the cough mechanism.
  • To investigate how TRP channel agonists and proinflammatory conditions affect cough.
  • To examine the influence of drugs on cough via TRP channels.

Main Methods:

  • Review of accumulating evidence on TRP channel function in cough.
  • Analysis of selective stimuli for TRP channels in provoking or inhibiting cough.
  • Examination of drug off-target effects on airway irritation and cough mediated by TRP channels.

Main Results:

  • Selective stimuli for TRP channels can provoke cough.
  • Cough threshold to TRP agonists is elevated in proinflammatory states.
  • Drugs like tiotropium and desflurane may exert effects on cough through TRPV1 and TRPA1 channels.

Conclusions:

  • TRP channels are crucial in initiating and potentiating cough.
  • These channels are activated by external irritants and internal inflammatory mediators.
  • Further research into TRP channels may yield novel therapeutic strategies for cough treatment.

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