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The Kidney Early Evaluation Program (KEEP) of Japan
Kosaku Nitta1, Kazuyoshi Okada, Mitsuru Yanai
1International Kidney Evaluation Association Japan (IKEAJ), Tokyo, Japan.
Insights
This study identified key risk factors for chronic kidney disease (CKD) in Japan. Controlling hypertension, diabetes, and high blood pressure is crucial for preventing CKD onset and progression.
Area of Science:
- Nephrology
- Public Health
- Epidemiology
Background:
- Chronic kidney disease (CKD) poses a significant public health challenge.
- Early detection and risk factor identification are crucial for managing CKD.
- The International Kidney Evaluation Association Japan (IKEAJ) initiative screens high-risk populations.
Purpose of the Study:
- To retrospectively analyze data from the KEEP Japan cohort.
- To identify risk factors associated with the onset and progression of CKD.
- To inform public health strategies for CKD prevention.
Main Methods:
- Retrospective analysis of data from 1,947 participants enrolled in KEEP Japan.
- Statistical examination to determine odds ratios for CKD occurrence.
- Inclusion criteria focused on participants screened by IKEAJ.
Main Results:
- Over 70% of participants did not have CKD; 7.5% were classified as high risk.
- Hypertension history and age over 60 were significant risk factors for CKD occurrence.
- Diabetes, cardiovascular disease, high blood pressure, anemia, and low HDL-C were associated with increased CKD risk.
Conclusions:
- Appropriate management of blood pressure, blood glucose, anemia, and HDL-C is vital.
- Targeted interventions for individuals with identified CKD risk factors can reduce disease incidence.
- Public health awareness and screening programs like IKEAJ are essential for CKD prevention.
Abstract:
The International Kidney Evaluation Association Japan (IKEAJ) was created to improve public health awareness of chronic kidney disease (CKD) by screening high-risk CKD populations. This study aimed to retrospectively examine data from KEEP Japan and detect the CKD risk factors for the onset and the progression of CKD. A total of 1,947 participants (mean age: 56.9 ± 16.4 years) to KEEP Japan were enrolled. More than 70% of the participants had no CKD. However, 7.5% of the participants were classified as high risk. The participants with a history of hypertension and older than 60 years had significantly higher odds ratio for occurrence of CKD. In addition, the participants with history of diabetes or cardiovascular disease, high blood pressure (BP), anemia, and low HDL-C had high odds ratios. It is therefore suggested that the appropriate control of BP, blood glucose, anemia, and HDL-C is important for populations with CKD risk factors to reduce the likelihood of CKD.
