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Updated: Apr 16, 2026

Murine Kidney Transplant Technique
Published on: October 20, 2015
Development of a kidney transplantation program--inverted funnel approach
Mitra Mahdavi-Mazdeh1, Alireza Heidary Rouchi, Seyed Mohammadreza Khatami
1Nephrology Research Center, Tehran University of Medical Sciences, Tehran, and Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Iran
Area of Science:
- Medical Science
- Transplant Surgery
- Public Health Policy
Background:
- Organ shortage is a global challenge with diverse national approaches.
- Iran's organ transplantation history offers a unique case study.
- This review examines Iran's inverted funnel approach to organ procurement.
Purpose of the Study:
- To analyze Iran's historical progression in organ transplantation.
- To elucidate the roles of government, professionals, and the public in organ donation.
- To understand the impact of policy and public engagement on organ availability.
Main Methods:
- Historical review of Iran's transplant program over two decades.
- Analysis of three distinct phases: living unrelated donation, brain death donation legislation, and implementation.
- Examination of sector-specific contributions (government, professionals, public).
Main Results:
- Kidney transplants from brain dead donors (BDDs) significantly increased from 0.4 pmp in 2000 to 15.1 pmp in 2013.
- Transplants from living donors showed a relative decrease during the same period.
- This shift indicates a growing reliance on deceased donor organs.
Conclusions:
- Governmental support for organ procurement from BDDs is crucial, driven by economic benefits and legislative backing.
- Professional engagement in public awareness, protocol adaptation, and training is vital.
- Public acceptance and participation are key to overcoming organ shortage through deceased donation.
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