[Unusual cutaneous angiofibromatosis following gold therapy of primary chronic polyarthritis]

An unusual case of late cutaneous intolerance reaction following gold therapy for rheumatoid arthritis is reported. In keloidlike angiofibromatoid lesions that were spread over the upper part of the trunk and the arms, perivascular macrophages carrying gold deposits inside lysosomes were detected with two recently introduced methods--energy-dispersive X-ray microanalysis (EDX) and electron spectroscopic imaging (ESI)--for definitive ultrastructural localization.