Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Electron Microscopy01:25

Overview of Electron Microscopy

16.6K
The wavelengths of visible light ultimately limit the maximum theoretical resolution of images created by light microscopes. Most light microscopes can only magnify 1000X, and a few can magnify up to 1500X. Electrons, like electromagnetic radiation, can behave like waves, but with wavelengths of 0.005 nm, they produce significantly greater resolution up to 0.05 nm as compared to 500 nm for visible light. An electron microscope (EM) can create a sharp image that is magnified up to 2,000,000X.
16.6K
Transmission Electron Microscopy01:15

Transmission Electron Microscopy

8.0K
In 1931, physicist Ernst Ruska—building on the idea that magnetic fields can direct an electron beam just as lenses can direct a beam of light in an optical microscope—developed the first prototype of the electron microscope. This development led to the development of the field of electron microscopy. In the transmission electron microscope (TEM), electrons are produced by a hot tungsten element and accelerated by a potential difference in an electron gun, which gives them up to 400...
8.0K
Chemical Ionization (CI) Mass Spectrometry01:21

Chemical Ionization (CI) Mass Spectrometry

1.7K
The molecular ion peak of a molecule in the mass spectrum provides vital information for molecular identification. However, conventional electron impact ionization can lead to the rapid dissociation of some molecular ions before they reach the detector. A milder ionization method is required to increase the lifetime of such ionized analyte molecules. Chemical ionization (CI) is a gas-phase protonation reaction useful for mass-analyzing analyte molecules that are easily protonated to yield the...
1.7K
Scanning Electron Microscopy01:07

Scanning Electron Microscopy

6.1K
A scanning electron microscope (SEM) is used to study the surface features of a sample by using an electron beam that scans the sample surface in a two-dimensional manner. Typically, areas between ~1 centimeter to 5 micrometers in width can be imaged. SEM can be used to image bacteria, viruses, tissues as well as larger samples like insects. Conventional SEM gives a magnification ranging from 20X to 30,000X and spatial resolution of 50 to 100 nanometers.
Fundamental Principles
Accelerated...
6.1K
Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

2.8K
In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acceptability of an integrated care program to identify patients at risk of advanced chronic liver disease in Australian primary care settings.

Australian journal of primary health·2026
Same author

Sociodemographic and clinical factors affecting advance care planning: results from a large community cohort in New South Wales, Australia.

Australian health review : a publication of the Australian Hospital Association·2025
Same author

Publisher's Note: "Vibrational signatures of dynamic excess proton storage between primary amine and carboxylic acid groups" [J. Chem. Phys. 160, 094311 (2024)].

The Journal of chemical physics·2025
Same author

Measuring scattering distributions in scanning helium microscopy.

Ultramicroscopy·2024
Same author

Vibrational signatures of dynamic excess proton storage between primary amine and carboxylic acid groups.

The Journal of chemical physics·2024
Same author

Structural Determination of Lysine-Linked Cisplatin Complexes via IRMPD Action Spectroscopy: NN<sub>s</sub> and NO<sup>-</sup> Binding Modes of Lysine to Platinum Coexist.

The journal of physical chemistry. B·2022
Same journal

Cluster assisted soft-landing hub (CLASH): An instrument for surface desorption and deposition using a pulsed cluster ion source.

The Review of scientific instruments·2026
Same journal

Influence of pre-ionization parameters on multi-channel discharge characteristics of field-distortion switch gaps.

The Review of scientific instruments·2026
Same journal

A Joule-Thomson low-temperature scanning tunneling microscope with vector magnet and rotatable scanning head.

The Review of scientific instruments·2026
Same journal

Fiber-optic triggering of a two-stage high-current linear transformer driver with laser energy below 100 μJ.

The Review of scientific instruments·2026
Same journal

Optimization of laboratory-scale x-ray absorption spectroscopy (XAS) apparatus for nuclear fuel research.

The Review of scientific instruments·2026
Same journal

Compressed multi-scale entropy and its application in mechanical fault diagnosis.

The Review of scientific instruments·2026
See all related articles

Related Experiment Video

Updated: Apr 16, 2026

Photoelectron Imaging of Anions Illustrated by 310 Nm Detachment of F&#8722;
06:53

Photoelectron Imaging of Anions Illustrated by 310 Nm Detachment of F−

Published on: July 27, 2018

9.3K

A highly contrasting scanning helium microscope.

A Fahy1, M Barr1, J Martens1

  • 1Centre for Organic Electronics, University of Newcastle, Callaghan, NSW 2308, Australia.

The Review of Scientific Instruments
|March 2, 2015
PubMed
Summary
This summary is machine-generated.

A new scanning helium microscope offers improved imaging quality and signal. This advanced design enables high-resolution, non-damaging surface analysis for various scientific applications.

More Related Videos

Demonstration of a Hyperlens-integrated Microscope and Super-resolution Imaging
10:01

Demonstration of a Hyperlens-integrated Microscope and Super-resolution Imaging

Published on: September 8, 2017

8.4K
Focused Ion Beam Lithography to Etch Nano-architectures into Microelectrodes
13:49

Focused Ion Beam Lithography to Etch Nano-architectures into Microelectrodes

Published on: January 19, 2020

7.3K

Related Experiment Videos

Last Updated: Apr 16, 2026

Photoelectron Imaging of Anions Illustrated by 310 Nm Detachment of F&#8722;
06:53

Photoelectron Imaging of Anions Illustrated by 310 Nm Detachment of F−

Published on: July 27, 2018

9.3K
Demonstration of a Hyperlens-integrated Microscope and Super-resolution Imaging
10:01

Demonstration of a Hyperlens-integrated Microscope and Super-resolution Imaging

Published on: September 8, 2017

8.4K
Focused Ion Beam Lithography to Etch Nano-architectures into Microelectrodes
13:49

Focused Ion Beam Lithography to Etch Nano-architectures into Microelectrodes

Published on: January 19, 2020

7.3K

Area of Science:

  • Surface science
  • Microscopy
  • Materials characterization

Background:

  • Scanning helium microscopy provides unique surface sensitivity and non-damaging imaging capabilities.
  • Previous designs had limitations in signal strength, affecting image quality and signal-to-noise ratio.

Purpose of the Study:

  • To present a novel scanning helium microscope design with enhanced performance.
  • To leverage unique contrast mechanisms for high-quality imaging.

Main Methods:

  • Development of a new scanning helium microscope.
  • Utilizing increased helium signal for improved contrast and signal-to-noise ratio.

Main Results:

  • Achieved an order of magnitude increase in available helium signal.
  • Demonstrated high-quality, intuitive imaging using topological contrast.
  • Improved signal-to-noise ratio for clearer data acquisition.

Conclusions:

  • The enhanced scanning helium microscope offers superior performance for surface analysis.
  • The design facilitates detailed topological imaging with minimal sample damage.
  • Paves the way for exploring advanced contrast mechanisms in helium microscopy.