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Updated: Apr 16, 2026
Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
[Short bowel syndrome and failure intestinal features in our community]
Jose Carlos Salazar Quero1, Javier Blasco Alonso2, Aurora Pérez Parras3
1Unidad de Gastroenterología, Hepatología y Nutrición Pediátricas. HHUU Virgen del Rocío.. josesolrac@hotmail.com.
Insights
Early enteral nutrition and reduced lipids in parenteral nutrition improve outcomes for pediatric short bowel syndrome (SBS) and intestinal failure (IF). These interventions help prevent liver disease and promote enteral autonomy in affected children.
Area of Science:
- Pediatric Gastroenterology
- Surgical Gastroenterology
- Clinical Nutrition
Context:
- Intestinal failure (IF) and short bowel syndrome (SBS) are increasingly prevalent in pediatric populations, often resulting from extensive bowel resections.
- Management of IF/SBS requires specialized care to ensure adequate nutrition and prevent complications.
Purpose:
- To investigate the prevalence, etiology, and management of SBS and IF in Andalusia.
- To analyze factors influencing patient outcomes, including transplant rates and time to enteral autonomy.
- To identify differences in clinical management across participating centers.
Summary:
- A multicenter retrospective study analyzed 25 pediatric patients diagnosed with SBS or IF between 2008 and 2014.
- Key findings indicate that early enteral nutrition introduction favors parenteral nutrition (PN) suspension and reduces the risk of parenteral nutrition-associated liver disease (PNALD).
- Reduced lipid administration in PN, longer remnant intestinal length, and earlier enteral nutrition also correlate with better PNALD prevention.
Impact:
- Highlights the critical role of early enteral nutrition in achieving enteral autonomy and improving outcomes for pediatric patients with SBS/IF.
- Provides evidence supporting specific nutritional strategies, such as reduced lipid PN, to mitigate complications like PNALD.
- Informs clinical practice guidelines for managing pediatric intestinal failure and short bowel syndrome.
Introduction:
Intestinal failure is being an entity with higher prevalence in the pediatric age, especially due to bowel resections causing the appearance of a short bowel syndrome.
Objectives:
To determine the prevalence and etiology of cases of short bowel syndrome (SIC) and Intestinal Failure (FI) existing in Andalusia. Analyze factors involved in evolution, the number of transplant patients and to know the time required to achieve enteral autonomy, studying whether there are differences in management between different participants.
Methods:
Multicenter retrospective descriptive observational study in which are collected data of patients diagnosed with short bowel syndrome or intestinal failure in 6 hospitals in Andalusia in the period from 1 January 2008 to 31 January 2014.
Results:
25 patients. Average age at diagnosis 7.4 months. Average length of remnant intestine: 113.8 cm; 64% of patients with <75 cm length remaining intestine. We show that: the early introduction of enteral nutrition is a factor favoring the suspension of the NP (p = 0'033); and that the prevention of liver disease associated with parenteral nutrition (EHANP) is favored by: the use of fewer lipid Parenteral Nutrition (p = 0'008), a greater length of remaining intestine (p = 0'049 ), the early introduction of enteral nutrition (p = 0'009) and a lower gestational age (p = 0'006).
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