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Overview of Systemic Arteries01:11

Overview of Systemic Arteries

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The human body is a complex, well-organized machine, and at the heart of its operations lies the circulatory system. This network of blood vessels, which includes systemic arteries, plays a vital role in maintaining life by transporting nutrients, oxygen, and waste products to and from cells throughout the body.
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Assessment of the Cardiovascular System III: Palpation01:27

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Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
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Vascular Spasm01:16

Vascular Spasm

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The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
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Vascular Resistance01:20

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Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Overview of Systemic Veins01:11

Overview of Systemic Veins

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Systemic veins are crucial blood vessels that return deoxygenated blood from various body tissues back to the heart. There are three systemic veins that return deoxygenated blood to the heart, they are as follows.
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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[Large vessels vasculopathy in systemic sclerosis].

Beatriz Tejera Segura1, Iván Ferraz-Amaro1

  • 1Servicio de Reumatología, Hospital Universitario de Canarias, Santa Cruz de Tenerife, España.

Medicina Clinica
|March 2, 2015
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis can cause severe large vessel vasculopathy, potentially leading to limb amputation. Early diagnosis and treatment are crucial for managing this understudied manifestation.

Keywords:
Esclerosis sistémicaGran vasoLarge vesselsSystemic sclerosisVasculopathyVasculopatía

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Area of Science:

  • Rheumatology
  • Vascular Medicine
  • Internal Medicine

Context:

  • Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis, vascular dysfunction, and immune dysregulation.
  • Vasculopathy in SSc classically involves microcirculation but can also affect proximal large vessels in the limbs.
  • Differential diagnosis of large vessel involvement in SSc includes vasculitis and atherosclerosis, posing diagnostic challenges.

Purpose:

  • To review the understudied manifestation of large vessel involvement in systemic sclerosis.
  • To highlight the prognostic and therapeutic implications of large vessel vasculopathy in SSc.
  • To emphasize the importance of early and accurate diagnosis for timely treatment initiation.

Summary:

  • Systemic sclerosis can lead to severe vasculopathy affecting not only microcirculation but also proximal large vessels.
  • This large vessel involvement in SSc, distinct from microvascular disease, can be challenging to differentiate from other conditions like vasculitis or atherosclerosis.
  • Prompt diagnosis and appropriate treatment are essential for managing this severe, potentially irreversible complication and preventing outcomes like amputation.

Impact:

  • Improved understanding of large vessel vasculopathy in SSc can lead to earlier diagnosis and intervention.
  • Timely management of SSc-related large vessel disease may prevent severe complications such as limb loss.
  • This review underscores the need for further research into the mechanisms and treatment strategies for large vessel involvement in systemic sclerosis.