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Updated: Apr 16, 2026

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
Cellular interactions in the pathogenesis of interstitial lung diseases
Gianluca Bagnato1, Sergio Harari2
1Unità Operativa di Reumatologia, Dipartimento di Medicina Clinica e Sperimentale, Azienda Ospedaliera Universitaria Gaetano Martino, Università degli studi di Messina, Messina, Italy gianbagnato@gmail.com.
Abstract:
Interstitial lung disease (ILD) encompasses a large and diverse group of pathological conditions that share similar clinical, radiological and pathological manifestations, despite potentially having quite different aetiologies and comorbidities. Idiopathic pulmonary fibrosis (IPF) represents probably the most aggressive form of ILD and systemic sclerosis is a multiorgan fibrotic disease frequently associated with ILD. Although the aetiology of these disorders remains unknown, in this review we analyse the pathogenic mechanisms by cell of interest (fibroblast, fibrocyte, myofibroblast, endothelial and alveolar epithelial cells and immune competent cells). New insights into the complex cellular contributions and interactions will be provided, comparing the role of cell subsets in the pathogenesis of IPF and systemic sclerosis.
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