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Related Concept Videos

Drug Therapy01:28

Drug Therapy

418
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
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Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

384
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
384
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

318
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
318
Therapeutic Drug Monitoring: Overview and Classification01:16

Therapeutic Drug Monitoring: Overview and Classification

574
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
574
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

314
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
314
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

569
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
569

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Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
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Technology-mediated interventions for enhancing medication adherence.

Niraj Mistry1, Arun Keepanasseril2, Nancy L Wilczynski3

  • 1Pediatric Outcomes Research Team (PORT), Division of Paediatric Medicine, Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Canada Department of Pediatrics, St. Michael's Hospital, University of Toronto, Toronto, Canada niraj.mistry@mail.utoronto.ca.

Journal of the American Medical Informatics Association : JAMIA
|March 2, 2015
PubMed
Summary
This summary is machine-generated.

Technology-mediated interventions (TMIs) show inconsistent effectiveness in improving medication adherence and clinical outcomes. More high-quality studies are needed to confirm their benefits for patients.

Keywords:
eHealthoutcomespatient adherencereminder systemssystematic reviewtechnology mediation

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Area of Science:

  • Health Informatics
  • Medical Adherence Research
  • Clinical Trial Analysis

Background:

  • Patient adherence to prescribed treatments remains a significant challenge despite available therapies.
  • Technology-mediated interventions (TMIs) are increasingly explored to enhance medication adherence.
  • Effective strategies are needed to improve patient compliance with medical regimens.

Purpose of the Study:

  • To evaluate the impact of technology-mediated interventions (TMIs) on medication adherence.
  • To assess the effects of TMIs on patient clinical outcomes.
  • To synthesize evidence from existing studies on technology's role in adherence.

Main Methods:

  • A secondary analysis of studies from an updated Cochrane review focusing on TMIs for medication adherence.
  • Inclusion of studies where information and communication technology or medical devices were central to the intervention.
  • Focus on studies with clear descriptions of technology components in adherence interventions.

Main Results:

  • Thirty-eight studies were reviewed, with only seven deemed low risk of bias.
  • TMIs encompassed education, self-monitoring, feedback, and electronic reminders, with telephone being common.
  • Fourteen studies reported significant improvements in both adherence and clinical outcomes.

Conclusions:

  • The effectiveness of TMIs for medication adherence and clinical outcomes is inconsistent.
  • A lack of high-quality studies necessitates cautious interpretation of current findings.
  • Further rigorous research is required to establish the definitive role of TMIs in patient care.