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A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Frequency of P2RX7 A1513C and TLR2 -196 to -174 ins/del in healthy Polish individuals
M Lewandowska1, P Garczyńska1, K Jędrychowska-Dańska1
1Department of Molecular Biology, Faculty of Biomedical Sciences and Postgraduate Education, Medical University, Lodz, Poland.
Abstract:
Polymorphisms within genes coding innate immune response proteins are involved in genetic susceptibility to various conditions. We investigated the frequency of P2RX7 A1513C and TLR2 -196 to -174 ins/del polymorphisms in healthy Polish population. Frequency of minor alleles was relatively similar to the pattern presented by Caucasian populations while it differed significantly when compared to non-European populations, which could be a result of variable selection pressure put upon studied alleles or hindered gene flow between populations.
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