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Preparation and Reactions of Thiols

Preparation and Reactions of Thiols

Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.

Preparation and Reactions of Sulfides

Preparation and Reactions of Sulfides

Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.

Catalysis

Catalysis

The presence of a catalyst affects the rate of a chemical reaction. A catalyst is a substance that can increase the reaction rate without being consumed during the process. A basic comprehension of a catalysts’ role during chemical reactions can be understood from the concept of reaction mechanisms and energy diagrams.

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Related Experiment Video

Updated: Apr 16, 2026

A Technique to Functionalize and Self-assemble Macroscopic Nanoparticle-ligand Monolayer Films onto Template-free Substrates

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Published on: May 9, 2014

New one-step thiol functionalization procedure for Ni by self-assembled monolayers.

Claudio Fontanesi¹, Francesco Tassinari¹, Francesca Parenti¹

¹†DSCG, University of Modena and Reggio Emilia, Via Campi 183, Modena 41125, Italy.

Langmuir : the ACS Journal of Surfaces and Colloids

|March 3, 2015

Summary

Researchers developed a quick method for creating self-assembled monolayers (SAMs) on nickel surfaces using cyclic voltammetry. This technique successfully formed high-quality ultrathin organic films with various molecules, confirmed by multiple surface analysis methods.

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Area of Science:

Surface Chemistry
Materials Science
Electrochemistry

Background:

Self-assembled monolayers (SAMs) are crucial for modifying surface properties.
Nickel surfaces are widely used in catalysis and electronics.
Developing efficient SAMs on nickel is important for advanced applications.

Purpose of the Study:

To report a facile and fast strategy for SAM functionalization of nickel surfaces.
To investigate the formation of ultrathin organic films using cyclic voltammetry.
To characterize the quality and properties of the formed films.

Main Methods:

Employing cyclic voltammetry (CV) cycling in tailored solutions for SAM formation.
Utilizing 1-hexadecanethiol (C16), L-cysteine (L-cys), and a chiral polymer (PCT-L) as adsorbing species.
Characterizing film formation using electrochemical methods and surface techniques.

Main Results:

Successful formation of high-quality ultrathin organic films on nickel surfaces.
Demonstrated effective SAMs using C16, L-cys, and the chiral polymer PCT-L.
Verified film formation through electrochemical analysis and surface characterization.

Conclusions:

The developed CV-based strategy is effective for rapid SAM functionalization of nickel.
High-quality ultrathin organic films can be reliably formed on nickel.
The study provides a robust method for surface modification of nickel with diverse organic molecules.