Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Depressed natural killer (NK) function in blood and marrow is related to the decrease in CD 11+ cells in acute

K Morikawa1, A Nakano, F Oseko

  • 1First Department of Internal Medicine, Shimane Medical University, Izumo, Japan.

Japanese Journal of Medicine
|July 1, 1989
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bayesian modeling of charge exchange recombination spectroscopy in fusion plasmas.

The Review of scientific instruments·2026
Same author

Results from the T2K Experiment on Neutrino Mixing Including a New Far Detector μ-like Sample.

Physical review letters·2026
Same author

First Measurement of the Electron-Neutrino Charged-Current Pion Production Cross Section on Carbon with the T2K Near Detector.

Physical review letters·2025
Same author

Near-infrared spectral variation in Ryugu particles and implication for rapid space weathering by solar UV radiation.

Scientific reports·2025
Same author

Neutron scattering and neural-network quantum molecular dynamics investigation of the vibrations of ammonia along the solid-to-liquid transition.

Nature communications·2024
Same author

Structural snapshots of V/A-ATPase reveal the rotary catalytic mechanism of rotary ATPases.

Nature communications·2022

Natural killer (NK) cell activity is significantly reduced in acute myelogenous leukemia (AML) patients. This impairment stems from a decrease in CD11+ cells with large granular lymphocyte morphology, affecting both binding and killing functions.

Area of Science:

  • Immunology
  • Hematology
  • Oncology

Background:

  • Natural killer (NK) cells are crucial for innate immunity, identifying and eliminating abnormal cells.
  • Acute myelogenous leukemia (AML) is a cancer of the blood and bone marrow characterized by rapid proliferation of abnormal white blood cells.
  • Dysregulation of immune cell function, including NK cells, is often observed in leukemia patients.

Purpose of the Study:

  • To investigate the functional activity of NK cells in patients diagnosed with AML.
  • To identify specific NK cell subsets and their characteristics contributing to impaired immune response in AML.

Main Methods:

  • NK cell activity was assessed in blood and bone marrow samples from AML patients using single-cell assays.
  • Functional capacities, including cell binding and cytotoxicity, were evaluated against target cell lines.

Related Experiment Videos

  • Surface phenotypic analysis (CD markers) and morphological examination for large granular lymphocytes (LGL) were performed.
  • Response to interferon stimulation was tested to assess effector cell responsiveness.

    • Main Results:

    • NK cell activity was significantly decreased in both blood and marrow of AML patients.
    • Both the binding and killing capacities of NK cells were profoundly depressed.
    • A significant reduction in CD11+ cell subsets and LGLs was observed in AML samples.
    • NK cells from AML patients showed poor responsiveness to interferon stimulation.

    Conclusions:

    • The impaired NK cell activity in AML is associated with a diminished CD11+ cell population exhibiting LGL morphology.
    • These findings highlight a specific immune deficit in AML, potentially impacting disease progression and treatment response.
    • Further research into modulating NK cell function could offer therapeutic strategies for AML.