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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Related Experiment Video

Updated: Apr 16, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
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Invasive onychocytic carcinoma.

Lei Wang1, Tianwen Gao1, Gang Wang1

  • 1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China.

Journal of Cutaneous Pathology
|March 3, 2015
PubMed
Summary

This study details a rare invasive onychocytic carcinoma, a malignant nail matrix tumor. Histopathology revealed specific keratin expressions, confirming its origin from nail matrix keratinocytes.

Area of Science:

  • Dermatopathology
  • Oncology
  • Keratinocyte Biology

Background:

  • Neoplasms of the nail matrix are uncommon.
  • Onychomatricoma and onychocytic matricoma are rare benign nail matrix tumors.
  • Onychocytic carcinoma is the malignant counterpart, with only one prior case reported.

Observation:

  • This report describes a case of invasive onychocytic carcinoma.
  • Histopathological examination of two biopsy specimens (early and invasive stages) was performed.
  • The specimens showed distinct cellular proliferation patterns and keratin expression profiles.

Findings:

  • The early-stage biopsy revealed a retiform proliferation of eosinophilic and basophilic cells.
  • The invasive-stage biopsy showed a retiform basophilic cell proliferation with focal keratinization.
Keywords:
carcinomanail matrix cellonychocytic

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  • Proliferating basophilic cells lacked expression of cytokeratin (CK)1, CK6, and CK10, but showed focal expression of hair-specific keratins (K31, K85, K86).

    • Implications:

    • These findings confirm the tumor's origin from nail matrix keratinocytes.
    • This case expands the understanding of rare malignant nail matrix tumors.
    • Further research into onychocytic carcinoma is warranted for improved diagnosis and treatment.