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Phenprobamate dependence: a case report.

Bahadir Demir1, Yasemin Demir2, Ihsan Aksoy1

  • 1Gaziantep University Medical Faculty, Psychiatry Department, Gaziantep, Turkey.

Addictive Behaviors
|March 3, 2015
PubMed
Summary
This summary is machine-generated.

Phenprobamate, a muscle relaxant, can be abused and lead to tolerance, with one patient using 16000 mg daily. This case highlights the abuse potential of centrally acting muscle relaxants and the need for careful prescribing.

Keywords:
DependencePhenprobamate

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Clinical Toxicology

Background:

  • Phenprobamate is a centrally acting muscle relaxant with sedative and anticonvulsant properties.
  • Centrally acting muscle relaxants possess abuse potential, primarily due to their sedative effects.
  • Existing literature documents the abuse of muscle relaxants like carisoprodol, meprobamate, and baclofen.

Observation:

  • This report details the first known case of phenprobamate abuse and tolerance.
  • The patient involved in this case report was consuming phenprobamate at a high dosage of 16000 mg per day.
  • The study underscores the potential for phenprobamate to be misused, similar to other centrally acting muscle relaxants.

Findings:

  • Phenprobamate abuse and tolerance can occur, necessitating clinical awareness.
  • High daily doses of phenprobamate were consumed by the patient, indicating significant tolerance.
  • The abuse potential of phenprobamate is linked to its pharmacological properties, including sedative effects.

Implications:

  • Prescribers should exercise caution when prescribing phenprobamate due to its abuse potential.
  • This case highlights the importance of monitoring patients for signs of tolerance and abuse with muscle relaxants.
  • Further research into the abuse potential and long-term effects of phenprobamate is warranted.