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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
[Neonatal hyperthyroidism and maternal Graves disease]
K Ben Ameur1, F Z Chioukh1, H Marmouch2
1Service de réanimation et de médecine néonatale, centre de maternité et de néonatalogie, EPS Fattouma-Bourguiba, 5000 Monastir, Tunisie.
Insights
Neonatal hyperthyroidism, a risk for infants born to mothers with Graves disease, requires careful monitoring and early treatment. Even asymptomatic newborns need hormonal testing to ensure timely intervention for Graves disease in infants.
Area of Science:
- Endocrinology
- Neonatology
- Obstetrics
Background:
- Graves disease in pregnant individuals poses a risk of neonatal hyperthyroidism.
- Early detection and management are crucial for affected newborns.
Observation:
- A term infant born to a mother with gestational Graves disease was initially asymptomatic.
- The infant later developed confirmed neonatal hyperthyroidism via hormonal assays.
Findings:
- Treatment with antithyroid drugs and propranolol resulted in a satisfactory clinical and biological course.
- Neonatal hyperthyroidism should be systematically screened for in infants of mothers with Graves disease.
Implications:
- The absence of early clinical signs does not rule out neonatal hyperthyroidism.
- Monitoring duration should be guided by initial hormonal test results for effective Graves disease management in newborns.
Abstract:
The onset of Graves disease during pregnancy exposes the neonate to the risk of hyperthyroidism. The newborn must be monitored and treatment modalities known to ensure early treatment of the newborn. We report on the case of an infant born at term of a mother with Graves disease discovered during pregnancy. He was asymptomatic during the first days of life, before declaring the disease. Neonatal hyperthyroidism was confirmed by hormonal assays. Hyperthyroidism was treated with antithyroid drugs and propranolol with a satisfactory clinical and biological course. Neonatal hyperthyroidism should be systematically sought in infants born to a mother with Graves disease. The absence of clinical signs during the first days of life does not exclude the diagnosis. The duration of monitoring should be decided according to the results of the first hormonal balance tests.
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