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Amylinamide, bone conservation, and pancreatic beta cells
1Department of Chemical Pathology, Royal Postgraduate Medical School, London.
Lancet (London, England)
|October 28, 1989
Abstract:
Amylinamide is a potent osteoclast-inhibiting peptide that is co-secreted with insulin from the beta cell. It induces profound hypocalcaemia in rats and rabbits and abolishes bone resorption by isolated osteoclasts in vitro. The non-amidated human peptide forms an insoluble fibrillar amyloid deposit that may interfere with beta-cell function and precipitate type II diabetes.