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p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis
Maria del Pilar Camacho Leal1, Marianna Sciortino1, Giusy Tornillo2
1Department of Molecular Biotechnology and Health Sciences, University of Torino, Italy.
Abstract:
BCAR1 (also known as p130Cas/BCAR1) is an adaptor protein that belongs to the CAS family of scaffold proteins. In the past years, increasing evidence has demonstrated the ability of p130Cas/BCAR1 to activate signaling originating from mechanical stimuli, cell-extracellular matrix (ECM) adhesion and growth factor stimulation cascades during normal development and disease in various biological models. In this review we will specifically discuss the more recent data on the contribution of p130Cas/BCAR1 in the regulation of tissue homeostasis and its potential implications in pathological conditions.
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