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Updated: Apr 16, 2026
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Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
Published on: July 28, 2023
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Hypertension: a systemic key to understanding local keloid severity
Juri Arima1, Chenyu Huang1,2, Bernard Rosner3
1Department of Plastic, Reconstructive, and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan.
Summary
Hypertension may worsen keloid severity, impacting keloid size and number. While not more common in keloid patients, screening for hypertension and using antihypertensive treatments may help manage skin fibrosis.
Area of Science:
- Dermatology
- Cardiology
- Epidemiology
Background:
- Keloids are a common skin fibrosis condition.
- The influence of systemic factors like hypertension on keloid severity is not well understood.
Purpose of the Study:
- To investigate the association between hypertension and keloid severity.
- To explore hypertension as a potential factor influencing keloid growth and prevalence.
Main Methods:
- Retrospective cross-sectional study of 304 keloid patients undergoing surgical treatment.
- Data collected included blood pressure, age, gender, keloid size, and number.
- Ordinal logistic regression analyses were used to assess associations.
Main Results:
- Blood pressure significantly correlated with both keloid size and number (p < 0.0001).
- Age also showed a significant association with keloid size (p < 0.0001).
- Hypertension prevalence in keloid patients was similar to the general Japanese population.
Conclusions:
- Hypertension may be an aggravating factor for keloid development and severity.
- This suggests skin could be a target organ for hypertension.
- Screening for hypertension and considering antihypertensive therapies may benefit keloid patients.
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