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Use of posaconazole delayed-release tablets for treatment of invasive aspergillosis

Marjorie M Conant1, Beverly E Sha, Laurie A Proia

  • 1Division of Infectious Diseases, Rush University Medical Center, Chicago, IL, USA.

Mycoses
|March 3, 2015
PubMed

Insights

Posaconazole tablets effectively treated a recurrent Aspergillus brain abscess in a patient who failed voriconazole therapy. This marks the first report of posaconazole tablets successfully treating invasive aspergillosis.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Neurology

Background:

  • Invasive aspergillosis, particularly brain abscesses, presents a significant treatment challenge.
  • Recurrence of Aspergillus infections after standard therapy necessitates exploring alternative treatment options.

Observation:

  • A 65-year-old male patient developed Aspergillus brain abscesses post-sinus aspergilloma resection.
  • Initial treatment with voriconazole for one year resulted in disease recurrence.

Findings:

  • Posaconazole delayed-release tablets were administered at a maintenance dose of 300 mg every 24 hours.
  • Therapeutic serum concentrations were achieved, demonstrating safety and clinical effectiveness in this case.

Implications:

  • This case suggests posaconazole tablets may be a viable treatment option for invasive aspergillosis, even when other therapies fail.
  • Further research is warranted to establish the role of posaconazole tablets in treating invasive aspergillosis beyond prophylaxis.
Keywords:
Posaconazoleantifungal therapyaspergillusinvasive mould infection

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