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Updated: Apr 16, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Enhancement of transdermal delivery of ibuprofen using microemulsion vehicle
Liandong Hu1, Qiaofeng Hu2, Jianxue Yang2
1College of Pharmaceutical Sciences, Hebei University, Baoding, China ; Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, China.
Objectives:
The objective of this study was to find a stable microemulsion vehicle for transdermal delivery of ibuprofen to improve the skin permeability.
Materials And Methods:
Microemulsion was prepared using different sorts of oils, surfactants and co-surfactants. Pseudo-ternary phase diagrams were used to evaluate the microemulsion domain. The effects of oleic acid and surfactant mixture on skin permeation of ibuprofen were evaluated with excised skins.
Results:
The optimum formulation F3 consisting of 6% oleic acid, 30% Cremophor RH40/Transcutol P (2:1, w/w) and 59% water phase, showed a high permeation rate of 42.98 µg/cm(2)/hr. The mean droplet size of microemulsion was about 43 nm and no skin irritation signs were observed on the skin of rabbits.
Conclusion:
These results indicated that this novel microemulsion is a useful formulation for the transdermal delivery of ibuprofen.
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