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Natural history and risk factors of atopic dermatitis in children

Bok Yang Pyun1

  • 1Pediatric Allergy and Respiratory Center, Department of Pediatrics, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.

Allergy, Asthma & Immunology Research
|March 3, 2015
PubMed

Insights

Atopic dermatitis (AD) often resolves by age 6-7, but many children still develop respiratory allergies like asthma later. This common inflammatory skin condition has variable courses throughout childhood.

Area of Science:

  • Pediatric Allergy and Immunology
  • Dermatology
  • Epidemiology of Allergic Diseases

Background:

  • Atopic dermatitis (AD) is a prevalent inflammatory skin condition in infants, often initiating the atopic march.
  • AD presents with pruritic skin lesions and exhibits variable disease trajectories.
  • Genetic factors and early severity can influence the persistence of childhood AD.

Purpose of the Study:

  • To describe the natural course and long-term outcomes of childhood atopic dermatitis.
  • To investigate the resolution rates of AD symptoms in children.
  • To examine the development of subsequent respiratory allergies in children with a history of AD.

Main Methods:

  • Review of cross-sectional and longitudinal studies on the natural history of atopic dermatitis.
  • Analysis of data regarding symptom resolution based on age.
  • Examination of the incidence of asthma and rhinoconjunctivitis in children with prior AD.

Main Results:

  • Approximately 40%-70% of childhood atopic dermatitis cases resolve by 6-7 years of age.
  • A significant proportion of children with resolved AD symptoms develop respiratory allergies.
  • Over half of children with AD experience the onset of respiratory allergies in later childhood.

Conclusions:

  • Childhood atopic dermatitis frequently resolves, but a substantial risk for developing asthma and other respiratory allergies persists.
  • Understanding the natural course of AD is crucial for managing allergic disease progression.
  • Early AD may serve as a critical predictor for the development of a broader allergic phenotype.

Keywords:
Natural historyatopic dermatitischildrenrisk factor

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