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Selectivity of excitotoxic mechanisms in Alzheimer's disease
1Andrus Gerontology Center, University of Southern California, Los Angeles 90089-0191.
Neurobiology of Aging
|September 1, 1989
Abstract:
Dysfunction of glutamatergic neurons in Alzheimer's disease may actually participate in some of the neurodegenerative processes via potential excitotoxic mechanisms. Two hypotheses are advanced which describe how a generalized excitotoxic mechanism could interact with unique metabolic properties of specific cell types leading to their selective vulnerability in Alzheimer's disease.