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Relationship between liver and low rumen pH in goat
1Key Laboratory of Animal Physiology and Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Genetics and Molecular Research : GMR
|March 3, 2015
Summary
High-concentrate diets reduce plasma lipopolysaccharide in goats with sub-acute ruminal acidosis. Liver proteins like aldehyde dehydrogenases and microsomal glutathione S-transferase are altered, suggesting a protective mechanism against acidosis.
Area of Science:
- Animal Science
- Veterinary Medicine
- Biochemistry
Background:
- Sub-acute ruminal acidosis (SARA) is a metabolic disorder in ruminants, often induced by high-concentrate diets.
- SARA can lead to systemic inflammation and liver dysfunction.
- Understanding the liver's response to SARA is crucial for managing goat health.
Purpose of the Study:
- To investigate the hepatic protein expression changes in dry dairy goats experiencing SARA.
- To analyze the liver's role in regulating lipopolysaccharide (LPS) levels during SARA.
- To identify specific proteins involved in the liver's protective response to low rumen pH.
Main Methods:
- Twelve Poll-goats were divided into high-concentrate (HG) and low-concentrate (LG) diet groups.
- SARA was induced in the HG group by maintaining rumen pH < 5.8 for over 3 hours.
- Proteomic analysis, mRNA abundance, and malondialdehyde content were measured in liver tissues.
Main Results:
- HG goats exhibited significantly lower plasma lipopolysaccharide concentrations compared to LG goats.
- Proteomic analysis revealed downregulation of aldehyde dehydrogenases and microsomal glutathione S-transferase, and upregulation of aldo-keto reductase in HG goats.
- Liver malondialdehyde content was decreased in the HG group, indicating reduced oxidative stress.
Conclusions:
- Hepatic protein expression is altered in response to low rumen pH during SARA in goats.
- The liver may play a protective role by modulating endogenous lipopolysaccharide and inhibiting aldehyde/peroxide formation.
- These findings highlight potential therapeutic targets for managing SARA in dairy goats.
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