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Genetic variations in the CYP4F2 gene, specifically the rs2108622 GG genotype and GGGT haplotype, are linked to an increased risk of ischemic stroke (IS) in the Han Chinese population.

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Area of Science:

  • Genetics
  • Neurology
  • Cardiovascular Science

Background:

  • Ischemic stroke (IS) is a leading cause of disability and mortality worldwide.
  • Understanding the genetic factors contributing to IS risk is crucial for developing targeted prevention strategies.
  • The CYP4F2 gene plays a role in various biological processes, but its association with IS remains underexplored.

Purpose of the Study:

  • To investigate the association between CYP4F2 gene polymorphisms and the risk of ischemic stroke in the Han Chinese population.
  • To identify specific single nucleotide polymorphisms (SNPs) and haplotypes within CYP4F2 that may confer susceptibility to IS.

Main Methods:

  • A case-control study design was employed.
  • Genotyping was performed for four CYP4F2 SNPs: rs2108622, rs3093100, rs3093105, and rs3093135.
  • Statistical analyses compared genotype and haplotype frequencies between IS patients and healthy controls.

Main Results:

  • The GG genotype of rs2108622 in the CYP4F2 gene was significantly associated with an increased risk of IS (P = 0.023).
  • Haplotype analysis revealed that the GGGT haplotype (comprising rs2108622-rs3093100-rs3093105-rs3093135) was also significantly associated with IS risk (P = 0.012).

Conclusions:

  • CYP4F2 gene polymorphism, particularly the rs2108622 GG genotype and GGGT haplotype, may represent a risk factor for ischemic stroke in the Han Chinese population.
  • These findings contribute to the understanding of the genetic underpinnings of ischemic stroke and may inform future genetic screening or therapeutic approaches.