Association between GSTM1 polymorphisms and lung cancer: an updated meta-analysis

Area of Science:

• Genetics
• Oncology
• Environmental Health

Background:

• Glutathione S-transferase M1 (GSTM1) genetic polymorphisms are investigated for their role in lung cancer susceptibility.
• Previous studies on the association between GSTM1 polymorphisms and lung cancer risk have yielded inconsistent results.

Purpose of the Study:

• To clarify the association between GSTM1 genetic polymorphisms and lung cancer risk through a comprehensive meta-analysis.

Main Methods:

• A meta-analysis was conducted using Revman 5.0 software.
• Literature retrieval, article selection, data collection, and statistical analysis were performed.
• A random-effect model was used to pool odds ratios (ORs) and 95% confidence intervals (CIs) from 38 eligible studies.

Main Results:

• The overall meta-analysis included 5737 lung cancer patients and 6843 cancer-free controls.
• No significant association was found between GSTM1 genetic polymorphisms and lung cancer risk (OR = 1.15, 95%CI = 0.98-1.36, P = 0.08).
• Analysis restricted to Chinese individuals also showed no association (OR = 1.13, 95%CI = 0.97-1.32, P = 0.13).

Conclusions:

• GSTM1 genetic polymorphisms are not associated with an increased risk of developing lung cancer.
• The findings suggest that GSTM1 genotype is not a significant risk factor for lung cancer across diverse populations.