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Relation between birth weight and weight and height at the age of 2 in children born preterm
Gayle Olson1, Steven J Weiner2, Dwight J Rouse3
1Department of Obstetrics and Gynecology, University of Texas Medical Branch Galveston, Galveston, Texas.
Insights
Customized birth weight percentile is a minor factor in preterm infants' weight at 2 years. This study found a weak association between fetal growth and later weight and height outcomes.
Area of Science:
- Pediatrics
- Neonatology
- Growth and Development
Background:
- Assessing fetal growth and its impact on long-term outcomes in preterm infants is crucial.
- Traditional birth weight standards may not accurately reflect individual growth potential.
Purpose of the Study:
- To evaluate the association between customized fetal growth percentiles and weight at 2 years in preterm infants.
- To determine if customized birth weight percentiles predict weight and height at 2 years.
Main Methods:
- Secondary analysis of a multicenter trial with 2-year follow-up of preterm infants.
- Calculation of customized birth weight percentiles using the Gardosi model.
- Regression analysis and z-score comparisons to assess the relationship between customized percentile and 2-year weight/height.
Main Results:
- Lower weight and height z-scores at 2 years were observed in preterm infants with birth weight below the 10th customized percentile compared to those at or above it.
- These differences persisted after adjusting for maternal education.
- While positive relationships existed between customized birth weight percentile and 2-year growth, they were weak.
Conclusions:
- Customized birth weight percentile plays a minor role in determining weight at 2 years for preterm infants.
- Further research may be needed to identify stronger predictors of growth in this population.
Objective:
The aim of the study was to evaluate associations between fetal growth and weight at 2 years in infants born preterm using a customized approach for birth weight.
Study Design:
This is a secondary analysis of a multicenter trial that included a 2-year follow-up of children born prematurely. Customized birth weight percentiles were calculated using the Gardosi model for a U.S. population, and the relation between customized percentile and weight and height at 2 years (adjusted for gender using z-score) was determined using regression analysis and by comparing z-scores for children with birth weight <10th versus ≥10th percentile.
Results:
Weight z-score at 2 years was significantly lower in the <10th than in the ≥10th percentile group (median [interquartile range, IQR]: -0.66 [-1.58, -0.01] vs. -0.23 [-1.05, 0.55]; p < 0.001), and remained after adjusting for maternal education (p < 0.001). A similar relationship was noted for height z-score between groups (median [IQR]: -0.56 [-1.29, 0.19] vs. -0.24 [-0.99, 0.37]; p < 0.001). Positive relationships between customized birth weight percentile and weight and height at 2 years were noted (p < 0.001 for both), but were not strong (R (2) = 0.04 and 0.02, respectively).
Conclusion:
Customized birth weight percentile is a minor determinant of weight at 2 years among children born preterm.
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