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Published on: August 30, 2024
Impact of varicocele on biological markers of gonadal function
E Blevrakis1, E Chatzidarellis2, D Anyfantakis3
1Department of Pediatric Surgery, University Hospital of Heraklion, Crete, Greece. e.blevrakis@med.uoc.gr.
Purpose:
The aim of this study is to evaluate the potential effect of varicocele in the hormonal and clinical profile of adolescents.
Methods:
Twenty adolescents at Tanner stage 4-5 with left varicocele were studied and compared with a control group of 20 healthy adolescents. All patients underwent ultrasonographic testicular volumetry as well as hormonal evaluation of inhibin B, testosterone, baseline and gonadotropin-releasing hormone stimulated, follicle-stimulating hormone as well as luteinizing hormone. Statistical analysis was performed using the student's t test with p value <0.05 taken as statistical significant.
Results:
Patients with varicocele showed reduced levels of inhibin B compared to controls and a significant reduction in the testicular volume on the affected side. The response of luteinizing hormone to gonadotropin-releasing hormone stimulation was significantly higher in the varicocele group compared to the control group. Furthermore a significant inverse relationship of inhibin B compared to follicle-stimulating hormone was noted.
Conclusion:
Serum inhibin B levels could represent a useful marker of Sertoli cell damage caused by varicocele.
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