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Vasculitis associated with connective tissue diseases.

E Cozzani1, G Gasparini, M Papini

  • 1Section of Dermatology, IRCCS AOU San Martino‑IST Di.S.Sal, University of Genoa, Genoa, Italy - emanuele.cozzani@unige.it.

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia
|March 4, 2015
PubMed
Summary
This summary is machine-generated.

Vasculitis in connective tissue disease (CTD) is rare, affecting about 10% of patients, with systemic lupus erythematosus (SLE) being most common. This review focuses on skin manifestations of CTD-associated vasculitis.

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Area of Science:

  • Rheumatology
  • Dermatology
  • Immunology

Background:

  • Vasculitis is rare in connective tissue disease (CTD), affecting ~10% of patients.
  • Systemic lupus erythematosus (SLE) has the highest association rate with vasculitis.
  • Classification of CTD-associated vasculitis is challenging, with current systems lacking specificity.

Purpose of the Study:

  • To review the cutaneous manifestations of vasculitis in connective tissue diseases (CTD).
  • To highlight the importance of skin findings in diagnosing systemic involvement.
  • To discuss the classification and diagnostic challenges of CTD-associated vasculitis.

Main Methods:

  • Literature review focusing on CTD-associated vasculitis and its cutaneous manifestations.
  • Analysis of classification systems, including the 2012 International Chapel Hill Consensus Conference.
  • Emphasis on diagnostic criteria and clinical presentation of skin lesions.

Main Results:

  • Small vessel vasculitis is most commonly reported in CTD.
  • Frequent cutaneous manifestations include petechiae, purpura, gangrene, and ulcers.
  • These skin findings are crucial for identifying potentially severe systemic vasculitis, such as cryoglobulinemic or necrotizing types.

Conclusions:

  • Cutaneous manifestations are key indicators of systemic vasculitis in CTD patients.
  • Improved classification and diagnostic approaches are needed for CTD-associated vasculitis.
  • Early recognition of skin lesions can lead to timely intervention for severe systemic disease.