Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

1.3K
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
1.3K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

2.0K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
2.0K
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

1.1K
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
1.1K
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

914
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
914
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

343
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
343
Revisionist Views of Adolescent and Adult Cognition01:24

Revisionist Views of Adolescent and Adult Cognition

438
A revisionist approach to Jean Piaget's theory of cognitive development has brought new insights that challenge and reinterpret his established ideas. Piaget proposed that the formal operational stage, emerging in adolescence, represents the culmination of cognitive maturity. During this stage, individuals are said to develop abstract thinking, engage in systematic problem-solving, and show a form of egocentrism, believing others are as preoccupied with their behavior as they are...
438

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain pathology in relation to somatic diseases: Exploring the body-brain crosstalk.

Journal of internal medicine·2026
Same author

Translation and cultural adaptation of Rowland universal dementia assessment scale (RUDAS) and European cross-cultural neuropsychological test battery (CNTB) into Italian.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

Retraction: Interventions against disability in frail older adults: Lessons learned from clinical trials.

The journal of nutrition, health & aging·2026
Same author

Culturally and linguistically diverse patients in an Italian memory clinic: lessons learned from the ImmiDem project.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

Activity of chemotherapy in mesenchymal chondrosarcoma: a multicentre retrospective analysis within the Italian Sarcoma Group network.

ESMO open·2026
Same author

The Impact of Delirium on Recovery in Geriatric Rehabilitation after Acute Infection.

Journal of the American Medical Directors Association·2024
Same journal

Corrigendum to "Probable respiratory sarcopenia trajectories and the risk of incident chronic diseases: findings from the China health and retirement longitudinal study" [J Nutr Health Aging, 30 (2026) 100903].

The journal of nutrition, health & aging·2026
Same journal

Associations of sarcopenia with the risk of incident respiratory disease and the role of inflammation and metabolism: a prospective cohort study.

The journal of nutrition, health & aging·2026
Same journal

Corrigendum to "Association of serum 25-hydroxyvitamin D with the risk of depression in individuals with prediabetes and diabetes: A prospective cohort study" [J Nutr Health Aging, 29 (2025) 100556].

The journal of nutrition, health & aging·2026
Same journal

Association between living arrangements in early old age and subsequent trajectories of protein intake among older adults in China.

The journal of nutrition, health & aging·2026
Same journal

Associations of adiponectin, leptin, and the adiponectin-to-leptin ratio with sarcopenia in older adults with cardiovascular-kidney-metabolic syndrome.

The journal of nutrition, health & aging·2026
Same journal

Association of artificial sweeteners intake and risk of CKD: a prospective cohort study.

The journal of nutrition, health & aging·2026
See all related articles

Related Experiment Video

Updated: Apr 16, 2026

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

903

Cognitive frailty: what is still missing?

M Canevelli1, M Cesari

  • 1Marco Canevelli, Memory Clinic, Department of Neurology and Psychiatry, "Sapienza" University, Viale dell'Università 30, 00185 Rome, Italy, Tel/fax +39 (0)6 49914604,

The Journal of Nutrition, Health & Aging
|March 4, 2015
PubMed
Summary
This summary is machine-generated.

Cognitive frailty, the co-occurrence of physical frailty and cognitive impairment, presents a novel target for age-related conditions. Further research is needed to define and validate this condition for clinical use.

More Related Videos

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

17.2K
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.6K

Related Experiment Videos

Last Updated: Apr 16, 2026

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

903
Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

17.2K
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.6K

Area of Science:

  • Gerontology
  • Neuroscience
  • Public Health

Background:

  • The relationship between physical frailty and cognitive decline is complex.
  • Cognitive frailty is a newly proposed condition characterized by both physical frailty and cognitive impairment.
  • This condition is distinct from overt dementia or other neurological disorders.

Purpose of the Study:

  • To discuss challenges in the clinical and research implementation of the cognitive frailty construct.
  • To highlight key areas requiring further investigation for cognitive frailty.
  • To explore the potential of cognitive frailty as a target for interventions.

Main Methods:

  • Literature review and conceptual analysis.
  • Discussion of definitional operationalization.
  • Examination of epidemiological and biological underpinnings.

Main Results:

  • The definition of cognitive frailty requires clear operationalization.
  • Epidemiological data supporting the construct need further development.
  • Underlying clinical and biological characteristics remain to be fully elucidated.

Conclusions:

  • Cognitive frailty is a promising construct for understanding and addressing age-related decline.
  • Clarification of its definition, epidemiology, and biological basis is crucial for its clinical application.
  • Further research is essential to validate and implement cognitive frailty as a target for preventive and therapeutic strategies.