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Antimicrobial and cytotoxic constituents from native Cameroonian medicinal plant Hypericum riparium

Michel Feussi Tala1, Ferdinand Mouafo Talontsi2, Guang-Zhi Zeng1

  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.

Fitoterapia
|March 4, 2015
PubMed

Keywords:
AntimicrobialButenolideCytotoxicityHypericum ripariumPhloroglucinolsXanthones

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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