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Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
A teenager presents with fulminant hepatic failure and acute hemolytic anemia
Somnath Bose1, Abraham Sonny2, Nadeem Rahman3
1From Critical Care Anesthesiology, Outcomes Research, and Cleveland Clinic Lerner College of Medicine, Anesthesiology Institute, Cleveland Clinic Foundation, Cleveland, OH..
Abstract:
A teenager was admitted to an outside hospital ED following an episode of melena. He had been complaining of intermittent abdominal pain, nausea, malaise, and easy fatigability for 2 months, with significant worsening of symptoms 2 weeks prior to this episode. He had no significant medical, surgical, or family history. On presentation at the outside ED, he was found to be profoundly icteric and encephalopathic. Initial laboratories suggested anemia, acute kidney injury, and acute liver failure, leading to a presumptive diagnosis of acute fulminant liver failure necessitating transfer to our institution.
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