Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recovery of male DNA acquired from carrion-feeding insects in a simulated sexual assault scenario.

Journal of forensic sciences·2026
Same author

Characterization of the oral microbiome in the diverse South African population by PacBio HiFi sequencing.

Applied microbiology and biotechnology·2026
Same author

Advances in biosensors for bacterial detection and identification.

World journal of microbiology & biotechnology·2025
Same author

The human skin microbiome: factors affecting individuality and application in forensic investigations.

International journal of legal medicine·2025
Same author

Forensic applications of compound genetic markers: trends and future directions.

Science & justice : journal of the Forensic Science Society·2025
Same author

The impact of dietary salt on the development of hypertension and gut microbiome dysbiosis in captive-bred vervet monkeys (Chlorocebus aethiops).

BMC veterinary research·2025

Related Experiment Video

Updated: Apr 16, 2026

DNA Methylation: Bisulphite Modification and Analysis
12:34

DNA Methylation: Bisulphite Modification and Analysis

Published on: October 21, 2011

106.9K

DNA methylation and application in forensic sciences.

Farzeen Kader1, Meenu Ghai1

  • 1Department of Genetics, School of Life Sciences, University of KwaZulu Natal - Westville Campus, Private Bag X 54001, Durban, KwaZulu Natal, South Africa.

Forensic Science International
|March 4, 2015
PubMed
Summary

DNA methylation, an epigenetic alteration, is vital for development and influenced by lifestyle. Differentially methylated regions (tDMRs) offer new forensic tools for identifying biological evidence and donor characteristics.

Keywords:
Body fluid identificationDNA methylationForensic sciencetDMRs

More Related Videos

Targeted DNA Methylation Analysis by Next-generation Sequencing
08:38

Targeted DNA Methylation Analysis by Next-generation Sequencing

Published on: February 24, 2015

38.3K
Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

10.4K

Related Experiment Videos

Last Updated: Apr 16, 2026

DNA Methylation: Bisulphite Modification and Analysis
12:34

DNA Methylation: Bisulphite Modification and Analysis

Published on: October 21, 2011

106.9K
Targeted DNA Methylation Analysis by Next-generation Sequencing
08:38

Targeted DNA Methylation Analysis by Next-generation Sequencing

Published on: February 24, 2015

38.3K
Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

10.4K

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Forensic Science

Background:

  • DNA methylation is a stable epigenetic modification crucial for mammalian development, evolving throughout life.
  • Epigenetic modifications, including DNA methylation, are influenced by aging, diet, and lifestyle.
  • Understanding DNA methylation may aid in preventing and treating age-related diseases.

Purpose of the Study:

  • To explore the role of DNA methylation in biological processes and its potential applications.
  • To highlight the utility of differentially methylated regions (tDMRs) in forensic science.
  • To identify novel tDMR markers for forensic DNA analysis.

Main Methods:

  • Genome-wide methylation analysis using high-throughput DNA technologies.
  • Identification and characterization of numerous differentially methylated regions (tDMRs).
  • Application of tDMR analysis for identifying biological fluids, tissues, and donor characteristics (sex, age, phenotype).

Main Results:

  • tDMRs have been identified that differ across various cell types and tissues.
  • tDMR analysis enables reliable identification of biological fluids and tissues.
  • Methods have been developed to determine the sex, age, and phenotype of DNA donors using tDMRs.

Conclusions:

  • DNA methylation analysis, particularly tDMRs, provides a powerful new technique for forensic investigations.
  • tDMRs serve as reliable markers for identifying biological evidence and inferring donor information.
  • Ongoing research aims to discover new tDMRs for enhanced forensic DNA analysis capabilities.