Related Experiment Video
Updated: Apr 16, 2026
12:29
Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
Published on: May 30, 2011
14.3K
Steady pulsed imaging and labeling scheme for noninvasive perfusion imaging
Jiadi Xu1,2, Qin Qin1,2, Dan Wu3
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Magnetic Resonance in Medicine
|March 4, 2015
Summary
A novel steady pulsed imaging and labeling (SPIL) scheme enables rapid, high-resolution multislice brain perfusion imaging in mice. This method accurately measures cerebral blood flow (CBF) in both healthy and ischemic conditions.
Area of Science:
- Biomedical Engineering
- Neuroimaging
- Magnetic Resonance Imaging
Background:
- Preclinical MRI requires advanced techniques for high-resolution brain perfusion imaging.
- Accurate measurement of cerebral blood flow (CBF) is crucial for studying neurological conditions.
Purpose of the Study:
- To propose and validate a steady pulsed imaging and labeling (SPIL) scheme for high-resolution multislice brain perfusion imaging in mice.
- To assess the capability of SPIL for robust CBF measurement using standard preclinical MRI equipment.
Main Methods:
- The SPIL scheme integrates a pulsed arterial spin labeling (PASL) module with extended mixing times for multislice acquisition.
- Image acquisition and magnetization recovery occur during the mixing times.
- A multipulsed imaging and labeling (MPIL) scheme was used to measure perfusion kinetic curves.
Main Results:
- High-resolution, five-slice CBF images were acquired in just 8 minutes in normal and ischemic mice.
- The SPIL method demonstrated clear reductions in CBF in the ischemic regions of affected mice.
- The technique proved free from magnetization transfer confounds, as shown in postmortem mouse studies.
Conclusions:
- The SPIL scheme offers a robust method for multislice CBF measurement in small animal models.
- This technique enhances preclinical neuroimaging capabilities with standard MRI equipment.
