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CT-1 induces angiogenesis by regulating the ADMA/DDAH Pathway

Zhen Zhong Zheng1, Xiao Tian Fu1,2, Jin Liang1

  • 1Department of Cardiology, The First Afficiated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, China.

Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
|March 4, 2015
PubMed
Summary

Cardiotrophin-1 (CT-1) promotes blood vessel formation by increasing endothelial cell proliferation and migration. This process involves the asymmetric dimethylarginine (ADMA)/dimethylargininase (DDAH) pathway, suggesting CT-1 regulates angiogenesis.

Keywords:
ADMADDAHangiogenesiscardiotrophin-1 (CT-1)eNOS

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