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Terfenadine blockade of exercise-induced bronchospasm
W E Pierson1, C T Furukawa, G G Shapiro
1Department of Pediatrics, University of Washington, Seattle.
Annals of Allergy
|November 1, 1989
Summary
Terfenadine effectively reduced exercise-induced bronchospasm and improved bronchodilation for up to four hours. This antihistamine demonstrated a dose-response effect, with higher doses providing greater benefits without adverse effects.
Area of Science:
- Pharmacology
- Respiratory Medicine
- Allergy and Immunology
Background:
- Exercise-induced bronchospasm (EIB) is a common condition.
- Antihistamines are widely used for allergic conditions.
Purpose of the Study:
- To evaluate the efficacy of terfenadine in treating exercise-induced bronchospasm.
- To assess the bronchodilatory effects of terfenadine.
Main Methods:
- A single-dose study involving terfenadine at 60, 120, and 180 mg.
- Administration four hours prior to exercise challenge.
- Assessment of bronchodilation and blockade of EIB post-exercise.
Main Results:
- Terfenadine provided significant bronchodilation for up to four hours.
- Significant blockade of exercise-induced bronchospasm was observed.
- A dose-response relationship was noted, with 180 mg showing the most significant effect.
- No adverse effects were reported.
Conclusions:
- Terfenadine is effective in managing exercise-induced bronchospasm.
- The drug offers bronchodilatory benefits.
- Terfenadine may also alleviate nasal congestion symptoms.