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CCR 20th anniversary commentary: In the beginning, there was PS-341
Beverly A Teicher1, Kenneth C Anderson2
1Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, Maryland. Beverly.Teicher@nih.gov teicherba@mail.nih.gov.
None:
Proteasome inhibitors have a 20-year history in cancer therapy. The first proteasome inhibitor, bortezomib, a breakthrough treatment for multiple myeloma, moved rapidly through development from the bench in 1994 to first FDA approval in 2003. Clinical Cancer Research has chronicled the development of proteasome inhibitors with publication of reports on bortezomib, carfilzomib, and the oral proteasome inhibitor ixazomib (MLN9708).
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